Friday, March 15, 2013

Ear Pain

Ear Pain

Pain in the ear is either due to a condition that directly affects the ear, or is referred from the surrounding areas. 

 

Ear pain is a common symptom that could occur either due to a problem in the ear itself or a neighboring part of the head or face. Ear pain due to a local cause is usually detected on ear examination. For example, an infection or a foreign body can be directly diagnosed through ear examination. If this examination does not show any abnormality, the surrounding structures like the mouth should also be examined.

The ear is made up of three parts: the external or outer ear, the middle ear and the inner ear. The external ear extends through the ear canal till the eardrum. The middle ear extends from the eardrum till a spiral structure called the cochlea, which forms the internal ear. Conditions that cause ear pain are usually located in the external or middle ear.

Common causes of ear pain are:

Conditions affecting the ear:

 Acute Otitis Externa: Otitis externa refers to infection of the external or outer ear. The patient complains of pain when the examiner pulls the cartilage of the ear or presses on the tragus (the small cartilaginous projection in front of the ear). The ear canal may be red and swollen. The infection may follow an insect bite, scratch or ear piercing.

 Acute Otitis Media: Acute otitis media is an infection of the middle ear and is one of the more common causes of ear pain. On examination of the ear, the eardrum may be red and bulging. In some cases especially in diabetes patients or patients with reduced immunity, the infection and pain can be severe; the condition is referred to as malignant otitis externa.

 Foreign Body in Ear: Foreign bodies inserted in the ears are common causes of ear pain in children. The foreign body is usually visible in the ear canal on examination and can be removed with a curette or a forceps. In some cases, excessive ear wax can result in ear pain.

 Changes in External Pressure: Changes in external pressure can result in ear pain. This situation is frequently experienced during a flight or while scuba diving. The pain usually subsides on its own. In some cases however, the pressure changes can damage the eardrum resulting in accumulation of fluid or blood in the middle ear.

 Trauma: Trauma to the ear due to injury can cause pain of the ear. A history of trauma is usually present in these patients.

 Cancer of the External Ear: Squamous cell cancer, a cancer affecting the external ear, is a rare cause of ear pain. The pain tends to be severe, deep and unrelenting.

 Ramsay Hunt Syndrome: Ramsay Hunt Syndrome is a condition where the nerves supplying to the area near the ear are affected by a viral infection called herpes zoster. The patient complains of features like ear pain, paralysis of the face and the presence of fluid-filled boils in the ear canal. Other associated symptoms include hearing loss, ringing in the ear, vertigo and taste disturbances.

 Relapsing Polychondritis: Relapsing polychondritis is a condition that affects the cartilages of different parts of the body including the ear. The ears appear red in color. However, the earlobe, which lacks cartilage, appears normal. The condition keeps relapsing. Cartilages in other organs are also often involved, which include the eyes, nose, heart, kidneys and the nervous system.

Conditions Causing Referred Pain to the Ear: Conditions that cause ear pain despite a normal ear examination are:

 TMJ Syndrome: The TMJ is the jaw joint. TMJ syndrome is a condition where the patient experiences ear pain especially while moving the jaw during activities like talking or chewing. Examination of the joint may elicit pain and a crepitus sound on moving the joint. The pain may subside with painkillers and a soft diet.

 Dental Causes: Pain in the molars due to caries, abscess or due to impaction of the molar can lead to referred pain in the ear. It is therefore extremely important to check the teeth in a patient complaining of ear pain.

 Sore Throat: Sore throat or enlarged and infected tonsils can result in ear pain. Again, this condition is diagnosed on examination of the mouth.

 Tumors of the face and neck region: Tumors of nose, mouth, neck and chest can rarely cause ear pain. The patient may show symptoms like difficulty with swallowing, hoarseness or weight loss. He/she may also give a history of smoking.

 Neuralgias: Neuralgias are conditions that affect nerves and cause severe pain in the distribution of the nerve. Neuralgias that cause severe pain around the face include trigeminal neuralgia, glossopharyngeal neuralgia and sphenopalatine neuralgia. The pain is often sharp, shooting, and severe and appears in paroxysms.

 Temporal Arteritis: Temporal arteritis is a condition that affects the blood vessels at the temple area. This pain may refer to the ear. The patient complains of pain when pressure is applied to the temporal arteries. The ESR test, which is a blood test, is usually abnormal in these patients.

 Cervical Spine Arthritis: Neck pain due to arthritis can also be referred to the ear. It is therefore necessary to examine the neck as well in a patient complaining of ear pain, especially if the ear examination is normal. 

Thursday, March 14, 2013

Herbs and Anti-oxidants that Fight Cancer



Nutrition, exercise, and stress reduction are the primary factors that help prevent development of free radicals in the body, build up the immune system and strengthen it.

Our immune system plays an important role in keeping free radicals in check, limiting the development of cancerous cells and combating  cancer.

What are these free radicals and why are they so dangerous?

The air we breathe in contains oxygen, a molecule that helps our body  to and function smoothly. Sometimes, metabolic processes, pollution in the air, smoking, and even junk food (yes, that’s right) can create unstable oxygen ions in the body. The oxygen radicals circulate in the bloodstream and ‘snatch’ electrons from the tissues thus destabilizing those ‘attacked’ molecules in the tissues  by making them short of electrons. They in turn circulate as free radicals on the lookout for molecules from which they can snatch electrons, thus kick-starting a  series of  chain reactions . This process is called ‘oxidative damage’.

Anti-oxidants are molecules that interact with free radicals and stop the chain reactions that damage the cells (including DNA) in our body. They help by destroying free radicals in the body and in the process reduce oxidative stress. Apart from building the immune system, they inhibit the gene expression for cancer and induce gene expression that promotes tumor suppression. . Further, they arrest uncontrolled cell division, thereby preventing the development of cancer.

Anti-oxidants that fight cancer include vitamin A, vitamin C, vitamin E, beta-carotene, phenolics and resveratrol among hundreds of other substances. And these are the substances that are easily available in most herbs and spices in your spice rack. Anti-oxidants in food are measured in units of Oxygen Radical Absorbance Capacity (ORAC). The FDA recommends 3,000 units of ORAC a day.

It’s true that you can’t get all the anti-oxidants you need from the herbs but the anti-oxidants in herbs can supplement the anti-oxidants you get from fruits and vegetables.

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Monday, March 11, 2013

Decreased Consciousness

Various levels of decreased consciousness include delirium, stupor, coma, persistent vegetative state, minimal conscious state and brain death.

Consciousness is a state of being aware of self and surroundings. It is decreased when large parts of the brain or specific parts which are associated with maintaining consciousness are affected by a disease process. There are various levels of decreased consciousness. These are:

 Delirium is a sudden severe state of confusion that is usually due to an illness.

 Stupor is a condition where the patient is unresponsive to normal stimuli but can be aroused by vigorous physical stimulation like excessive shaking or pinching.

 Coma is a state in which a person cannot be aroused even with vigorous stimuli.

 Persistent vegetative state is a condition where a person shows some improvement following a coma, and appears to lie motionless and without awareness and higher mental activity. It occurs when the brain hemispheres cannot work and the functions are taken over by the lower centers like the brainstem and the thalamus. These patients usually die after months or years, but rare cases of partial recovery have been encountered in clinical practice.

 Minimally conscious state is a condition where the patient exhibits inconsistent signs of consciousness. The patients show some degree of awareness of self and surrounding.

 Locked-in state is a condition where the patient is conscious and aware of the surroundings but unable to move. The patient can only respond by opening and closing the eyes.

 Brain death is a state where the patient suffers from irreversible coma with loss of ability to maintain body functions including breathing.

In cases where the cause can be reversed, the patient may recover completely if there is no accompanying brain damage. In some cases, the patient needs continuous ventilatory support.

A history obtained from the patient’s attendants often helps to diagnose the underlying cause of decreased consciousness. Some features that could help in the diagnosis are:

 A high temperature may indicate infection, heat stroke or drug overdose.

 Decreased consciousness in a diabetic may be due to a low or high blood sugar level.

 An abrupt decrease in consciousness could be due to a bleed in the brain or its immediate surrounding, or a brainstem stroke. A slower decrease could indicate a tumor.

 An abnormally low temperature may be due to prolonged exposure to cold, hypothyroidism, excessive alcohol or medication intake, or infection in older people.

 A metabolic cause should be suspected if the patient suffered from intoxication or agitated delirium before the decrease in consciousness.

 An absence of response to painful stimuli in one limb may indicate a problem in the brain. Absent responses of limbs on both sides could indicate that the brain stem is involved.

 Pinpoint pupils that respond to light may indicate opioid poisoning. Examination of eye movements helps to localize the site of the lesion.

Some of the tests that could assist in the diagnosis of the cause of decreased consciousness are:

 Blood tests: An abnormal liver or kidney function test may indicate liver or kidney failure, respectively. A low blood sugar level indicates hypoglycemia.

 A CT scan or MRI can detect brain tumors or structural damage to the brain.

 A spinal tap may show the presence of meningitis or a bleed around the brain.

Causes of decreased levels of consciousness are listed below:

Conditions that decrease oxygen, glucose or cofactors supply to the brain: Conditions that deprive the brain of its requirements to function properly result in an altered level of consciousness. These include:

 Alterations in glucose levels: High blood sugar levels can lead to diabetic coma. On the other hand, low glucose levels can lead to hypoglycemic coma. An altered level of consciousness in a diabetic should raise the suspicion of a problem in blood sugar level.

 Cardiac causes: A cardiac arrest results in a reduced supply of oxygen-rich blood to the brain. Other heart conditions like heart failure could cause similar problems. These conditions may be diagnosed with an ECG or other cardiac tests. Low blood pressure could also result in decreased blood supply to the brain.

 Lung diseases: Severe lung conditions like chronic obstructive pulmonary disease, pulmonary edema (fluid in the lungs), pulmonary embolism (a clot in the lungs), and severe and long-lasting asthma attacks can reduce oxygen content of the blood and thereby the supply to the brain and result in brain damage. A difficulty with breathing is usually obvious in these patients.

 Deficiency of B group of vitamins: A person with severe deficiency of vitamin B1 or thiamine suffers from beriberi, which sometimes causes confusion and delusions. Deficiency of the vitamin B3 or niacin results in pellagra, which is also associated with confessional states. In addition, the patient shows digestive problems and skin inflammation.

Metabolic, Hormonal and Other General Conditions: Metabolic conditions result in the accumulation of excessive or toxic substances in the blood resulting in decreased consciousness: Some of these conditions are listed below:

 Liver failure: Liver failure results in the accumulation of toxic substances in the body, which affect the brain and reduce consciousness, even leading to hepatic encephalopathy and coma. Other signs of liver failure may be present like accumulation of fluid in the abdomen and jaundice.

 Kidney failure: Kidney failure results in high levels of urea in the body, which could affect the level of consciousness. Other features of kidney failure may be present in these patients.

 Hypothyroidism: Very low or very high thyroid levels are associated with altered consciousness. Very low levels could result in a type of coma called myxedema coma.

 Hypothermia or hyperthermia: A change in temperature can affect the brain resulting in damage. High temperatures tend to affect the brain more as compared to lower temperatures.

 Abnormal sodium levels:
High sodium levels in the blood, which is often a consequence of dehydration, can reduce consciousness. On the other hand, hyponatremia or low sodium levels could result in accumulation of fluid in the brain, again affecting the level of consciousness.

Drugs, Alcohol and Poisons: Consciousness could be affected by substances that act on the brain. A history of intake of these substances may be obtained from the patient’s relatives. Some of these are:

 Drugs: Drugs are often the cause of an altered level of consciousness in older individuals. This is especially in the case of drugs that act on the brain like sedatives and opioids. Older people are more sensitive to medications and often take multiple medications. Dosages if not reduced in these individuals can result in decreased consciousness. People who take drugs that could possibly reduce their level of consciousness are advised to avoid using machinery or drive to avoid accidents. They are also advised to avoid alcohol due to the additive effect in reducing brain function.

 Alcohol: Alcohol affects the brain in multiple ways. It can directly affect the brain cells causing them to function slowly. In addition, it can affect lung function and reduce the oxygen supply to the brain.

 Poisoning: Poisoning with carbon monoxide results in reduced oxygen-rich blood to the brain.

Conditions affecting the brain: Conditions that directly affect either both the cerebral halves of the brain or the reticular activating system of the brainstem (which is responsible for arousal) can result in reduced levels of consciousness. These conditions are diagnosed based on a detailed neurological examination and tests like CT scan and MRI. These conditions include:

 Stroke: A stroke can affect consciousness in a number of ways. It decreases blood supply to the areas of the brain involved in maintaining consciousness like the brainstem and the cerebrum. A bleed within or just outside the brain can exert pressure on the brain or result in irritation.

 Brain tumors / abscess: A brain tumor or abscess can occupy space within the skull and exert pressure on a part of the brain. In some cases, it can press on the brain excessively damaging it and even pushing it through some of the openings at the base of the skull. This situation is referred to as herniation of the brain, which can worsen the patient’s condition. The tumor may also directly affect the areas of the brain controlling consciousness. Breathing may be altered in these patients. Examination of the eyes helps in the diagnosis of these conditions.

 Aneurysms in the brain:
An aneurysm is a swelling of a blood vessel of the brain. It could affect consciousness by exerting pressure on the brain or resulting in a bleed.

 Head injury: Head injury may damage the brain and cause loss of consciousness, sometimes even leading to coma. In some cases, the head injury results in a bleed within the skull. The bleed puts pressure on a part of the brain and can result in decreased consciousness.

 Seizures:
Following a seizure, the patient sometimes goes into a deep sleep. This is referred to as the post-ictal stage.

 Infections: Infections of the brain called encephalitis, or the covering of the brain called meningitis can result in altered levels of consciousness. The neck of the patient may be rigid in cases of meningitis. Besides, sepsis may also affect the brain, altering the consciousness levels.

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